CALL FOR PAPERS Physiology and GI Cancer In Barrett’s esophagus patients and Barrett’s cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids
نویسندگان
چکیده
Sui Peng,* Xiaofang Huo,* Davood Rezaei, Qiuyang Zhang, Xi Zhang, Chunhua Yu, Kiyotaka Asanuma, Edaire Cheng, Thai H. Pham, David H. Wang, Minhu Chen, Rhonda F. Souza, and Stuart Jon Spechler Esophageal Diseases Center, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, Department of Internal Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas; Department of Surgery, VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas; Department of Research and Development, VA North Texas Heath Care System, Dallas, Texas; Department of Pediatrics, Children’s Medical Center and the University of Texas Southwestern Medical Center, Dallas, Texas; Division of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
منابع مشابه
In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids.
Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects against DCA-induced injury in vivo in patients and in vitro using nonneoplastic, telomerase-immortalized Barret...
متن کاملProposed Use of Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in a Treatment Regimen for Barrett’s Esophagus
Citation: Stamp D. (2016). Proposed Use of Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in a Treatment Regimen for Barrett’s Esophagus. M J Canc. 1(2): 007. INTRODUCTION Huo et al [1] first placed 250 uM of the hydrophobic bile acid (DCA) into the esophagus of patients with Barrett’s esophagus (BE) and left it there for 5 min. The DCA was dissolved in alcohol. Subsequent examination o...
متن کاملTranslational Physiology Mechanisms of oxidant production in esophageal squamous cell and Barrett’s cell lines
Feagins LA, Zhang HY, Zhang X, Hormi-Carver K, Thomas T, Terada LS, Spechler SJ, Souza RF. Mechanisms of oxidant production in esophageal squamous cell and Barrett’s cell lines. Am J Physiol Gastrointest Liver Physiol 294: G411–G417, 2008. First published December 6, 2007; doi:10.1152/ajpgi.00373.2007.—We hypothesized that differences among individuals in reflux-induced oxidant production by es...
متن کاملBile acids directly augment caudal-related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett’s epithelium Running title: Bile acids and Cdx2
Background & Aims: The mechanism of transformation to intestinal metaplasia in Barrett’s oesophagus has not been clarified. We investigated the effects of various bile acids on the expression of the caudal-related homeobox gene Cdx2 in cultured oesophageal squamous epithelial cells. In addition, morphological and histochemical changes of squamous cells to intestinal epithelial cells were studie...
متن کاملDysregulation of PARP1 is involved in development of Barrett’s esophagus
AIM To investigate the potential role of poly(ADP-ribose) polymerase 1 (PARP1) in the development of Barrett's esophagus (BE). METHODS A BE mouse model was established to examine the esophageal morphological changes and molecular changes. Microarray analysis was performed to compare the gene expression profiles between BE patients and healthy controls. qPCR was used to examine the PARP1 expre...
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